Journal of organic chemistry article template

Notes are concise accounts describing novel observations, new methods of wide applicability or interest, or focused studies of general interest.

Notes differ from Articles in having a narrower scope. The level of experimental rigor, including compound characterization, required for a Note is the same as that for an Article. The length of a Note is limited to 3, words, which includes the abstract, introductory paragraph, results and discussion, and space occupied by tables and graphics; the word count limit does not include the experimental section, acknowledgments, supporting information availability statement, and list of references.

Tables and graphics count toward the word-count limits at the rate of 50 words per vertical inch for one-column items 8. JOC Synopses are brief focused reviews of current topics of interest to organic chemists written by active researchers that include work from their own laboratories. Manuscripts that describe newly emerging areas of research are encouraged. JOC Synopses are invited by the Editor-in-Chief but voluntary submissions will be considered and screened before a formal review.

They are limited to 4, words of text, not counting acknowledgments and the list of references, and are limited to no more than 80 references and endnotes.

All graphics and tables combined must be able to fit on two standard word- processor pages. Perspectives are personal overviews of specialized research areas by acknowledged experts. They are published only by invitation of the Editor-in-Chief. Details on length and other requirements will be provided to authors. While this document will provide basic information on how to prepare and submit the manuscript as well as other critical information about publishing, we also encourage authors to visit the ACS Publishing Center for additional information on everything that is needed to prepare and review manuscripts for ACS journals and partner journals, such as.

All ACS journals and partner journals have simplified their formatting requirements in favor of a streamlined and standardized format for an initial manuscript submission. Read more about the requirements and the benefits these serves authors and reviewers here.

The templates facilitate the peer review process by allowing authors to place artwork and tables close to the point where they are discussed within the text. Learn more about document templates here. A cover letter must accompany every manuscript submission. During the submission process, you may type it or paste it into the submission system, or you may attach it as a file. The cover letter should include a brief paragraph pointing out the significance of the reported work.

The order of these components is recommended as shown, but we give authors flexibility to change the order of items to best fit their manuscript.

Claims of priority, originality, convenience, effectiveness, or value should be avoided or used with great restraint. In addition, editors may ask authors to moderate or remove what they judge to be excessive use of subjective evaluative language elsewhere in the manuscript. Section Headings. The title should be descriptive of the topic of the article and as short as possible, using easily searchable keywords and minimizing hyphenation.

Avoid using abbreviations and acronyms unless they are more commonly used than spelled out words. Also avoid complex compound names as much as possible in the title by using generic names, and spell out elements rather than using symbols unless part of a compound name. Neither the title nor any other text should indicate that the article is part of a numbered series on a broader research topic, or a numbered contribution from a particular institution or research group.

Abbreviations, Symbols, Units, Compound Names. Authors are encouraged to use abbreviations and acronyms in the text to conserve space.

A list is available to assist with common examples. Nonstandard abbreviations and acronyms must be defined the first time they are used in the abstract and in the text. The use of abbreviations should be consistent throughout the manuscript text and graphics. Full systematic names of compounds see The ACS Style Guide for guidance should be included in the Experimental Section on first mention and for brevity assigned a molecule number for reference throughout the article.

In the Introduction, Results and Discussion, and Conclusions, authors should use their judgement on common usage of compound names or use molecule numbers in lieu of full systematic names. The abstract for an Article or Note should briefly state the purpose of the research, principal results, and major conclusions. A well-written abstract can attract the attention of potential readers and increase the likelihood that the published article will be cited by other researchers. Undefined nonstandard abbreviations and reference citation numbers should be avoided.

For a JOC Synopsis or Perspective, the abstract should identify the scope and focus of the manuscript. The length of the abstract for an Article or Perspective should not exceed words. See Appendix 2 for full details on graphics requirements. A graphic must be included with each manuscript for display in the Abstract and Table of Contents TOC , fitting in an area no larger than 8.

Ensure that cartoon depictions of machinery, nature, and processes do not indicate actions or settings that are improbable. The introduction should include sufficient background information to provide appropriate context as to the novelty and importance of the new work and clearly state the purpose and objectives of the research.

An extensive review of prior work is not appropriate, and documentation of the relevant background literature should be selective rather than exhaustive, particularly if reviews can be cited. The opening paragraph of a Note or JOC Synopsis serves a similar function but is briefer and is not labeled as an Introduction section.

Results and Discussion. The presentation of experimental details in the results and discussion section should be kept to a minimum. Reiteration of information that is made obvious in tables, figures, or reaction schemes should be avoided. If an optional conclusion section is provided, its content should not substantially duplicate the abstract.

For Notes and Articles, manuscripts reporting the results of experimental work must include all experimental procedures, compound characterization data, and any associated literature citations. Authors have the flexibility to place the experimental content in the main text Experimental Section , in the Supporting Information, or a combination of both as it best supports the manuscript, so long as the information is accurate and complete.

As needed, authors may substitute or also include a section on Computational Methods. These sections should describe methods in sufficient detail to permit repetition of the work by others. The Data Requirements section should be consulted for guidance on reporting synthetic experimental, compound characterization, spectroscopic, crystallographic, computational, and bioassay data in the Experimental Section, Computational Methods, and Supporting Information. A general Experimental Methods paragraph may be optionally provided to document procedures, such as purification methods, solvent removal, and spectroscopic and chromatographic analyses, that are common to most of the individual procedures, and should be placed at the beginning of the Experimental Section.

Authors should be judicious in citing the literature; unnecessarily long lists of references should be avoided. Authors must also cite any previously published work wherein portions of the submitted work have been disclosed. It is seldom necessary or appropriate for an author to cite more than 10 of their own publications, except in a Perspective or JOC Synopsis. Long endnotes should be avoided; peripheral discussion should be placed in the supporting information.

Endnotes should not contain graphics, experimental procedures, or compound characterization data. For a JOC Synopsis, a high-resolution dpi or better , in focus, color head-and-shoulders photograph and statement should be furnished for each coauthor. Model release and copyright forms are required for author photographs and will be provided by the Journal office.

This information is provided to the reviewers during the peer-review process for Review Only and is available to readers of the published work for Publication.

Supporting Information must be submitted at the same time as the manuscript. If the manuscript is accompanied by any supporting information files for publication, these files will be made available free of charge to readers. A brief, nonsentence description of the actual contents of each file is required. This description should be labeled Supporting Information and should appear before the Acknowledgement and Reference sections.

Examples of sufficient and insufficient descriptions are as follows:. When including supporting information for review only, include copies of references that are unpublished or in-press. These files are available only to editors and reviewers. All ACS journals strongly encourage authors to make the research data underlying their articles publicly available at the time of publication. Research data is defined as materials and information used in the experiments that enable the validation of the conclusions drawn in the article, including primary data produced by the authors for the study being reported, secondary data reused or analyzed by the authors for the study, and any other materials necessary to reproduce or replicate the results.

For Notes and Articles, every manuscript reporting the results of experimental work must include an Experimental Section, with all experimental procedures, compound characterization data, and any associated literature citations appearing in the manuscript: Authors may use their discretion to place the information in the main text or in the Supporting Information, depending on the relevance to the Results and Discussion section.

The Experimental Section should describe methods in sufficient detail to permit repetition of the work by others. The editors remind authors that it is unethical to modify reported data or spectra, for example to correct spectral baselines or remove solvent or impurity peaks.

General Experimental Methods. A General Experimental Methods paragraph may be optionally provided to document procedures such as purification methods, solvent removal, and spectroscopic and chromatographic analyses that are common to most of the individual procedures, and it should be placed at the beginning of the Experimental Section. Sources of reactants, reagents, and solvents should not be identified except for 1 starting compounds that are unusual or not widely available; 2 materials for which the author has reason to suspect that the source is critical to the outcome of an experiment; and 3 catalysts.

In the latter two cases, available purity information should be reported. Experiments involving a catalyst, enzyme, or reagent that is neither commercially available nor prepared by a fully described or cited nonproprietary method may not be reported. All data needed to document structure assignments, purity assessments, and other conclusions should be included in the manuscript and Supporting Information.

Synthesis Experiments. Synthesis procedures for new compounds should be accompanied by yields and the most important product characterization data. Graphic structures of synthesized products but not reaction schemes or other graphics may accompany the characterization data listings. When known compounds have been prepared, procedures that were reported in the Experimental Section or Supporting Information of a previous publication should be cited but not reported in detail unless they have been modified.

Fully characterized compounds should have bolded compound names and structure numbers as the titles of the paragraphs in which their preparation, isolation, purification, and properties are described.

Intermediates in multistep sequences that have not been purified and fully characterized should not have their names bolded; their preparation and partial characterization should be described as a step in the synthesis of a fully characterized bold-titled compound. Reactant, reagent, and catalyst quantities should be given in both weight and molar units. Reaction solvent volumes and reaction times should be reported.

Use of standard abbreviations or unambiguous molecular formulas for reagents and solvents, and of structure numbers rather than chemical names to identify starting materials and intermediates, is encouraged.

All reported yields should represent weighed amounts of isolated and purified products and must be reported in the Experimental Section as both weights and percentages. When a series of related compounds has been prepared using substantially the same procedure, it is usually sufficient to present a single representative example.

If instead a general synthesis procedure reporting only relative molar quantities as equivalents is presented, the relative solvent volume also needs to be reported as the molarity of the limiting reactant or reagent in the reaction mixture. When chromatographically or spectroscopically determined conversions of starting material to product are presented in a table documenting a synthetic transformation using a range of starting materials, reagents, or reaction conditions, a column heading or footnote should identify which quantity is being reported.

The isolation and purification of the products for several representative examples should be reported in the Experimental Section, and the yields of isolated product for those examples should be included in the table. Manuscripts that illustrate a new or modified synthetic method with multiple examples conducted on a submillimolar scale should include one or more examples carried out on a larger scale to demonstrate the practical utility of the method as a synthetic tool.

When preparative chromatography is used for product purification, both the stationary phase and solvent should be identified. Where different solvent mixture ratios, or different gradient elution schemes, have been used for purifying the members of a series of related compounds whose preparation is described with a single example or a single general procedure, the mixture composition or gradient scheme should be individually reported for each compound.

For reactions that require heating, identify the temperature and heat source oil bath, heating mantle, etc. Reports of syntheses conducted in microwave reactors must indicate whether sealed or open reaction vessels were used, how the reaction temperature was monitored external surface sensor or internal probe type , and the temperature reached or maintained in each experiment. JOC does not publish reports of studies conducted with domestic kitchen microwave ovens in which yields or selectivities observed using microwave irradiation are compared with results obtained using conventional heating.

For light-promoted reactions, report the light source: type of lamp along with manufacturer and model or type of lights, wavelength of peak intensity or broadband source, and available information about the spectral distribution and intensity; the identity and quantity or concentration of any photocatalyst or sensitizer; the material of the irradiation vessel if other than borosilicate glass; the distance from the light source to the irradiation vessel; and the use of any filters.

JOC further encourages authors to consider the Principles of Green Chemistry in carrying out their research and consider reporting metrics such as atom economy, mass efficiency, E-factor, or others. JOC upholds a high standard for compound characterization to ensure that compounds being added to the chemical literature have been correctly identified and can be synthesized in reported yield and purity.

For new compounds, evidence adequate to establish both identity and degree of purity homogeneity must be provided.

Purity documentation must also be provided for known compounds whose preparation by a new or modified literature method is reported. JOC requires that purity be documented compound-by-compound, with copies of spectra or chromatograms, elemental analysis, or quantitative NMR or chromatographic integration data. For combinatorial libraries containing more than 20 new compounds, complete characterization data must be provided for at least 20 diverse members of each structural type. Full characterization is not required for new compounds prepared solely as derivatives for analytical purposes for example, Mosher esters prepared for assigning absolute configuration.

Authors are responsible for retaining their original data or having available original data from collaborators or from contractors who perform analyses on their behalf. Authors may be asked to provide copies of spectra or analytical reports if an editor or reviewer raises a question about reported results. JOC provides a Compound Characterization Checklist for authors to use when reporting new compounds or when reporting known compounds that have been prepared by new or modified methods.

Known compounds that have been synthesized by literature methods or obtained from commercial sources should not be listed, but appropriate references or sources should be cited in the manuscript. The Checklist, which was previously required, is now optional, as the editors recognize enhanced efficiencies in data reporting and JOC has a rigorous data-checking process as part of manuscript evaluation.

Nevertheless, authors are highly encouraged to use the checklist for their own benefit and to help editors and reviewers more quickly assess the thoroughness of the characterization of compounds and the reporting of computational results. The Compound Characterization Checklist will not be published.

If required data cannot be obtained a compound is too insoluble to record a carbon NMR, or too unstable to obtain a good elemental analysis, etc. When the preparation of known compounds by a new or modified method is reported, it is only necessary to report the yields, cite the published characterization data, and document the purity, usually by inclusion of proton NMR spectra or chromatograms in the Supporting Information see section on Purity below. It is not necessary to include detailed NMR, IR, and MS peak listings in either the Experimental Section or Supporting Information unless erroneous data in the literature are being corrected, or unless the data are being reported for the first time.

Detailed synthesis procedures and listings of characterization data should not be included for these compounds unless the literature procedure has been substantially modified, or new physical or spectroscopic data are being presented.

Mixtures of regioisomers, geometric isomers, and diastereomers but not usually enantiomers are generally expected to be separated, and the components individually characterized. When the components cannot be successfully separated and the individual gravimetric yields determined, the combined yield and the mole fraction of each component should be reported in the Experimental Section, and the spectroscopic or chromatographic method by which the composition was determined should be identified.

The formatting of spectroscopic, physical, analytical, and other product characterization data should adhere to the recommendations in The ACS Style Guide , except that NMR and accurate mass HRMS data should be reported as discussed below. For compounds that have been prepared by more than one method, the description in the Experimental Section and the purity documentation usually a proton NMR spectrum in the Supporting Information should clearly identify which method provided the sample whose yield and purity are documented.

Where other types of physical and spectroscopic methods are useful or necessary for confirming structure assignments, it is appropriate to include a summary of the data in the Experimental Section, but except as noted below, these additional data types are not generally required for routine compound characterization in JOC.

Proton and carbon NMR resonances should be listed for each new compound, with the normal full range of chemical shifts displayed usually 10—0 ppm for proton; —0 ppm for carbon ; the solvent and instrument frequency should be identified. Proton NMR shifts, reported to 0. Carbon NMR peak shifts should be rounded off to the nearest 0.

For compounds with carbon-bonded fluorine atoms, the carbon peak multiplicity d, t, q and coupling in Hz should be reported. Authors using software for automated data analysis are reminded to check numerical data, including proton counts and coupling constants, before including them in the manuscript. For products isolated as inseparable isomer mixtures, if the NMR absorptions can be attributed to individual isomers, the NMR chemical shift data for those isomers should be reported in two or more separate lists, one for each isomer, instead of as a single list.

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